Integrating pangenomics and metagenomics: Understanding feedbacks between horizontal gene transfer and microbiome dynamics Staff and students of the University of Liverpool and University of Manchester are invited to this symposium, which will examine two main questions: 1. What is the Impact of pangenome dynamics on the microbiome? Our focus here is on how movement of genes and mobile genetic elements between taxa can influence overall microbiome dynamics 2. How does microbiome context shape pangenome evolution?Here we examine the impact of community diversity and microbe-microbe interaction on processes of horizontral gene transfer. We welcome offers to present a 15 minute talk or poster. If you would like to do so, please provide a title and brief abstract upon registration. We aim to include a diversity of study systems and organisms - welcoming work on environmental microbiomes as well as host-associated microbiomes in different compartments (e.g. lung, skin, gut, rhizosphere, leaf) and different host taxa (e.g. human, animal, plant). We are also keen to represent organismal and mobile genetic element diversity, encompassing both prokaryotic and eukaryotic microbes. As always, we particularly value early career researcher contributions. We are grateful to the Liverpool Microbiome Innovation Centre for funding this symposium. Organisers: Greg Hurst (Liverpool) Mike Brockhurst (Manchester)